The developer behind the excellent series of EverDrive flash carts has shown PAPRIUM running on an actual Mega Drive via the Mega EverDrive Pro.
In a series of tweets on X, as well as replies from the community, Krikzz has confirmed that their mapper (linked below) will be open source and made available to the wider community. So hopefully someone from the MiSTer FPGA community can benefit from Krikzz’s work and get PAPRIUM working on either the Mega Drive or the Mega CD core. Time will tell, but we are all hoping for the best.
Link to mapper